Jordi Remon, Laura Mezquita, David Planchard, Cecile Jovelet, Ludovic Lacroix, Etienne Rouleau, Karen Howarth, Vincent Plagnol, Clive Morris, Emma Green, Cecile LePechoux, Caroline Caramella, Julien Adam, Benjamin Besse

Clinical validation and utility of InVision ctDNA in advanced non-small cell lung cancer (NSCLC) patients
MAP2018
Read more

Jordi Remon, Sandra Ortiz-Cuaran, Laura Mezquita, Aurelie Swalduz, Karen Howarth, Cecile Jovelet, Ludovic Lacroix, Etienne Rouleau, Frank De Kievit, Katherine Baker-Neblett, Simon Roitt, Vincent Plagnol, Clive Morris, Emma Green, Maurice Perol, David Planchard, Pierre Saintigny, Benjamin Besse

Clinical outcomes in patients with advanced NSCLC treated with targeted therapies, with actionable mutations identified by InVisionFirstctDNA assay
MAP2018
Read more

Nicolas Guibert, MD, Greg Jones, John Beeler, PhD, Vincent Plagnol, PhD, Jean Mourlanette, Myriam Delaunaya, Anne Casanova, Gilles Favre, PhD, Anne Pradines, PhD, Julien Mazieres, MD, PhD

Early prediction of outcomes to PD1 inhibitors in non-small cell lung cancer using next generation sequencing of plasma circulating tumor DNA
ASCO 2018
Read more

L Mezquita, C Jovelet, L Lacroix, D Planchard, G Recondo, E Pailler, E Auclin, V Plagnol, K Howarth, C Morris, E Green, E Rouleau, C Nicotra, C Caramella, J Adam, N Auger, F Farace, L Friboulet, B Besse

An Amplicon-Based Liquid Biopsy For Detecting ALK and ROS1 Fusions And Resistance Mutations In Advances Non-Small Cell Lung Cancer (NSCLC) Patients
ASCO 2018
Read more

Sandra Ortiz-Cuaran, Aurélie Swalduz, Camille Léonce, Solène Marteau, Séverine Martinez, Gilles Clapisson, Virginie Avrillon, Luc
Odier, Lionel Falchero, Pierre Fournel, Emma Green, Clive Morris, Maurice Pérol, Pierre Saintingy.

Longitudinal circulating-tumor DNA profiling of EGFR-mutated non-small cell lung cancer patients treated with EGFR-tyrosine kinase inhibitors
AACR2018 - Please contact us for more information on this poster
Read more

Samuel Woodhouse, Vincent Plagnol, Karen Howarth, Stefanie Lensing, Matt Smith, Michael Epstein, Mikidache Madi, Sarah Smalley, Catherine Leroy, Jonathan Hinton, Frank de Kievit, Esther Musgrave-Brown, Colin Herd, Katherine Baker-Neblett, Will Brennan, Peter Dimitrov, Nathan Campbell, Nitzan Rosenfeld, James Clark, Davina Gale, Jamie Platt, John Calawa2, Greg Jones and Tim Forshew

Analytical validation of InVisionFirst™, a liquid biopsy assay for high-sensitivity broad molecular profiling of circulating tumor DNA using plasma samples of cancer patients
AACR2018 - Please contact us for more information on this presentation
Read more

 L Mezquita, Y Hu, K Howarth, C Jovelet, D Planchard, L Lacroix, A Swalduz, S Ortiz-Cuaran, V Avrillon, V Plagnol K Baker-Neblett, G Jones, N. Rosenfeld, C Morris, E Green, ES Kim, M Perol, P Saintigny, SV Liu, GR Oxnard, B Besse

Feasibility of an amplicon-based liquid biopsy assay for ALK and ROS1 gene fusions in advanced non-small cell lung cancer patients
AACR2018
Read more

Vincent Plagnol, Samuel Woodhouse, Karen Howarth, Stefanie Lensing, Matt Smith, Michael Epstein, Mikidache Madi, Sarah Smalley, Catherine Leroy, Jonathan Hinton, Frank de Kievit, Esther Musgrave-Brown, Colin Herd, Katherine Baker-Neblett, Will Brennan, Peter Dimitrov, Nathan Campbell, Clive Morris, Nitzan Rosenfeld, James Clark, Davina Gale, Jamie Platt, John Calaway, Greg Jones, Tim Forshew

Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling
PLOS ONE, March, 2018
Read more

Davina Gale , Andrew R. J. Lawson, Karen Howarth, Mikidache Madi, Bradley Durham, Sarah Smalley, John Calaway, Shannon Blais, Greg Jones, James Clark, Peter Dimitrov, Michelle Pugh, Samuel Woodhouse, Michael Epstein,
Ana Fernandez-Gonzalez, Alexandra S. Whale, Jim F. Huggett, Carole A. Foy, Gerwyn M. Jones, Hadas Raveh-Amit, Karin Schmitt,
Alison Devonshire, Emma Green, Tim Forshew, Vincent Plagnol, Nitzan Rosenfeld

Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA
PLOS ONE, March 2018
Read more

Nicolas M. Guibert, Yuebi Hu, Nora Feeney, Vincent Plagnol, Greg Jones, Karen Howarth, John Beeler, Cloud P. Paweletz, Geoffrey R. Oxnard

Amplicon-based next-generation sequencing of plasma cell-free DNA for detection of driver and resistance mutations in advanced non-small cell lung cancer
Annals of Oncology, 09 January 2018
Read more

Nicolas M. Guibert, Yuebi Hu, Nora Feeney, Michael Epstein, Samuel Woodhouse, Karen Howarth, Vincent Plagnol, John Beeler, Greg Jones, Cloud P. Paweletz, Geoffrey R. Oxnard

Amplicon-based next-generation sequencing (NGS) of plasma cell-free DNA (cfDNA) for detection of driver and resistance mutations in advanced NSCLC
World Conference on Lung Cancer, Yokohama, Japan
Read more

Laura Mezquita, Cecile Jovelet, Maud Ngocamus, Edouard Auclin, Jordi Remon, Emma Green, Vincent Plagnol, Clive Morris, Anas Gazzah, Caroline Caramella, Julien Adam, Ludovic Lacroix, Luc Friboulet, Jean-Charles Soria, Benjamin Besse, David Planchard

Liquid biopsies for monitoring brafv600e mutation in advanced brafv600e non-small cell lung cancer (NSCLC)
World Conference on Lung Cancer 2017, Yokohama, Japan
Read more

Charlotte Fribbens, Isaac Garcia Murillas, Matthew Beaney, Sarah Hrebien, Ben O’Leary, Lucy Kilburn, Karen Howarth, Michael Epstein, Emma Green, Nitzan Rosenfeld, Alistair Ring, Stephen Johnston, Nicholas Turner

Tracking evolution of aromatase inhibitor resistance with circulating tumour DNA analysis in metastatic breast cancer
Annals of Oncology, 04 October 2017
Read more

Charlotte Fribbens, Isaac Garcia-Murillas, Matthew Beaney, Sarah Hrebien, Karen Howarth, Michael Epstein, Nitzan Rosenfeld, Alistair Ring, Stephen Johnston and Nicholas C. Turner

Tracking evolution of aromatase inhibitor resistance with circulating tumor DNA in metastatic breast cancer
ASCO2017, Chicago
Read more

Besse B, Remon J, Lacroix L, Mezquita L, Jovelet C, Howarth K, Plagnol V, Morris C, Nicotra C, Pannet C, Green E, Soria JC.

Evaluation of liquid biopsies for molecular profiling in untreated advanced non-small cell lung cancer (NSCLC) patients
ASCO2017, Chicago
Read more

Remon J, Besse B, Lacroix L, Mezquita L, Jovelet C, Howarth K, Plagnol V, Morris C, Nicotra C, Pannet C, Green E, Soria JC

Evaluation of liquid biopsies for molecular profiling in advanced non-small cell lung cancer (NSCLC) patients in the relapse treatment setting
ASCO2017, Chicago
Read more

Nicolas M Guibert, Cloud Paweletz, Yuebi Hu, Nora Feeney, Vincent Plagnol, Valerie Poole, Greg Jones, Geoffrey Oxnard

Early detection of competing resistance mutations using plasma next-generation sequencing in patients with EGFR-mutant NSCLC treated with osimertinib
ASCO2017, Chicago
Read more

Penelope A. Bradbury, Keyue Ding, Peter M. Ellis, Lesley Seymour, Frank De Kievit, Greg Jones, Clive Morris, Emma, Green, Glenwood D. Goss, Ming Sound Tsao, Frances A. Shepherd

Evaluation of stored liquid biopsies for molecular profiling in non-small cell lung cancer (NSCLC) patients
ASCO2017, Chicago
Read more

Catenacci DVT, Green E, Epstein M, Jones G, Morris C, O’Day E, Lomnicki S, Maranto M, Karrison T, Kindler

Molecular profiling of advanced pancreatic cancer (PC) patients from a phase I/II study using circulating tumor DNA
ASCO2017, Chicago
Read more

J. Remon, C. Caramella, C. Jovelet, L. Lacroix, A. Lawson, S. Smalley, K. Howarth, D. Gale, E. Green, V. Plagnol, N. Rosenfeld, D. Planchard, M. V. Bluthgen, A. Gazzah, C. Pannet, C. Nicotra, E. Auclin, J. C. Soria and B. Besse

Osimertinib benefit in EGFR-mutant NSCLC patients with T790M-mutation detected by circulating tumour DNA.
Annals of Oncology, April 2017
Read more

Jonathan C. M. Wan, Charles Massie, Javier Garcia-Corbacho, Florent Mouliere, James D. Brenton, Carlos Caldas, Simon Pacey, Richard Baird and Nitzan Rosenfeld

Liquid biopsies come of age: towards implementation of circulating tumour DNA
Nature Reviews Cancer, April 2017
Read more

Isaac Garcia-Murillas, Matthew Beaney, Michael Epstein, Karen Howarth, Andrew Lawson, Sarah Hrebien, Emma Green, Nitzan Rosenfeld and Nicholas C. Turner

Comparison of enhanced Tagged-Amplicon Sequencing and digital PCR for circulating tumor DNA analysis in advanced breast cancer
AACR, Washington USA, April 2017
Read more

Christine A. Parkinson, Davina Gale, Anna Piskorz, Heather Biggs, Charlotte Hodgkin, Helen Addley, Sue Freeman, Penelope Moyle, Evis Sala, Karen Sayal, Karen Hosking, Ioannis Gounaris, Mercedes Jimenez-Linan, Helena M. Earl, Wendi Qian, Nitzan Rosenfeld, James Brenton

Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study
PLOS Medicine, 20 December, 2016 - Research was conducted through CRUK, not Inivata.
Read more

Remon J, Caramella C, Jovelet C, Lacroix L, Lawson A, Smalley S, Howarth K, Gale D, Rosenfeld N, Green E, Plagnol V, Planchard D, Bluthgen MV, Gazzah A, Pannet C, Nicotra C, Soria JC, Besse B

Osimertinib benefit in ctDNA T790Mpositive, EGFR-mutant NSCLC patients
WCLC, Vienna, December 2016
Read more

Tim Forshew, Andrew Lawson, Sarah Smalley, Vincent Plagnol, John Calaway, Shannon Blais, Karen Howarth, Greg Jones, Michelle Pugh, Mikidache Madi, Bradley Durham, Esther Musgrave-Brown, Samuel Woodhouse, Nitzan Rosenfeld, Davina Gale, Emma Green and James Clark

Analytical performance and validation of an InVision® circulating tumour DNA sequencing assay across two laboratories
WCLC, Vienna, December 2016
Read more

Karen Howarth, John Calaway, Sarah Smalley, Shannon Blais, Andrew Lawson, Greg Jones, Davina Gale, Michelle Pugh, Mikidache Madi, Bradley Durham, Esther Musgrave-Brown, Samuel Woodhouse, Tim Forshew, Emma Green, Vincent Plagnol, Nitzan Rosenfeld and James Clark

Analytical performance and validation of an enhanced TAm-Seq™ circulating tumour DNA sequencing assay across two laboratories
NCRI 2016, Liverpool, UK, November 2016
Read more

Remon J, Soria JC, Planchard D, Jovelet C, Pannet C, Lacroix L, Gazzah A, Lawson A, Smalley S, Howarth K, Gale D, Green E, Plagnol V, Rosenfeld N, Oulassen K, Besse B

Liquid biopsies for molecular profiling of mutations in non-small cell lung cancer (NSCLC) patients lacking tissue samples
MAP 2016, London, UK, September 2016
Read more

Remon J, Soria JC, Lacroix L, Howarth K, Lawson A, Smalley S, Gale D, Plagnol V, Green E, Rosenfeld N, Planchard D, Jovelet C, Pannet C, Besse B

Evaluation of liquid biopsies for molecular profiling and monitoring in advanced non-small cell lung cancer (NSCLC) patients
ASCO 2016, Chicago, US, June 2016
Read more

Remon J, Soria JC, Planchard D, Jovelet C, Pannet C, Lacroix L, Gazzah A, Lawson A, Smalley S, Howarth K, Gale D, Green E, Plagnol V, Rosenfeld N, Olaussen K, Chaput N, Besse B

Liquid biopsies for molecular profiling of mutations in non-small cell lung cancer (NSCLC) patients lacking tissue samples
AACR 2016, New Orleans, US, April 2016
Read more

Davina Gale, Vincent Plagnol, Andrew Lawson, Michelle Pugh, Sarah Smalley, Karen Howarth, Mikidache Madi, Bradley Durham, Vasudev Kumanduri, Kitty Lo, Peter Dimitrov, Jordi Remon, Benjamin Besse, James Clark, Emma Green, Nitzan Rosenfeld, Tim Forshew

Analytical performance and validation of an enhanced TAm-Seq™ circulating tumor DNA sequencing assay
AACR Annual Meeting, New Orleans, US, April 2016
Read more

Davina Gale, Jordi Remon, Andrew RJ Lawson, Sarah Smalley, Esperanza Perez, Karen D Howarth, Michelle Pugh, Abdelaziz Fahem, Tim Forshew, Amanda Bettison, John Beeler, Ludovic Lacroix, Emma Green, Michael Stocum, Vincent Plagnol, Benjamin Besse, Nitzan Rosenfeld

Assessment of clinical applications of circulating tumour DNA in lung cancer using an enhanced TAm-Seq™ platform
International Association for the Study of Lung Cancer Conference, Denver, September 2015
Read more

Sarah Smalley, Davina Gale, Andrew RJ Lawson, Jordi Remon, Esperanza Perez, Michelle Pugh, Karen D Howarth, Mehdi Touat, Jean-Charles Soria, Antoine Hollebecque, Emma Green, Benjamin Besse, Tim Forshew, Vincent Plagnol, Ludovic Lacroix, Nitzan Rosenfeld

Assessing the clinical applications of ctDNA in patients with advanced stage metastatic cancer using our enhanced TAm-Seq™platform
Molecular Targets and Cancer Therapeutics, Boston, November 2015
Read more

Murtaza M, Dawson SJ, Tsui DW, Gale D, Forshew T, Piskorz AM, Parkinson C, Chin SF, Kingsbury Z, Wong AS, Marass F, Humphray S, Hadfield J, Bentley D, Chin TM, Brenton JD, Caldas C, Rosenfeld N.

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
Nature. 2013 May 2;497(7447):108-12. doi: 10.1038/nature12065. Epub 2013 Apr 7. PubMed PMID: 23563269.
Read more

Dawson SJ, Tsui DW, Murtaza M, Biggs H, Rueda OM, Chin SF, Dunning MJ, Gale D, Forshew T, Mahler-Araujo B, Rajan S, Humphray S, Becq J, Halsall D, Wallis M, Bentley D, Caldas C, Rosenfeld N.

Analysis of circulating tumor DNA to monitor metastatic breast cancer
N Engl J Med. 2013 Mar 28;368(13):1199-209. doi: 10.1056/NEJMoa1213261. Epub 2013 Mar 13. PubMed PMID: 23484797.
Read more

Forshew T, Murtaza M, Parkinson C, Gale D, Tsui DW, Kaper F, Dawson SJ, Piskorz AM, Jimenez-Linan M, Bentley D, Hadfield J, May AP, Caldas C, Brenton JD, Rosenfeld N.

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA.
Sci Transl Med. 2012 May 30;4(136):136ra68. doi: 10.1126/scitranslmed.3003726. PubMed PMID: 22649089.
Read more